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Zofran covers to drug’s group antiemetics. The mechanism of action has not been fully clarified, supposedly therapeutic effect of the remedy is carried out using oppression of serotonin 5HT3 receptors of the central and peripheral nervous system, their stimulation occurs during chemotherapy, increasing the release of serotonin. The medication is not sedating and does not affect the level of prolactin in the plasma. After intake preparation is well absorbed from the gastroenteric tract. Peak plasma concentration of the active ingredient is noted after 1.5 hours after oral dose's administration, and six hours after rectal administration. While taking the medicament at the same time eating bioavailability is increasing. The half-life of Zofran 8mg 90 pills is up to 3 hours, in the elderly - 5 hours, after rectal application - about 6 hours (due to more prolonged absorption in the rectum). In patients with severe impairment of kidney function the half-life is increased to 15-20 hours. The pharmacokinetics of the drug is the same for single and repeated use. In patients with severe hepatic impairment there is marked decrease in systemic clearance of the active ingredient, increasing of the half-life (15-32 hours) and oral bioavailability (100%). The medicament is applied to cure and prevent emesis in patients who are receiving cytotoxic chemotherapy or radiotherapy. It is also indicated for the prevention and also treatment of nausea or possible vomiting in patients who undergoing surgery. So nowadays you have a good possibility to buy Zofran online not leaving the home.