Atomoxetine covers to sympathomimetics of central action. Remedy is a highly potent inhibitor of presynaptic norepinephrine transporter and has also minimal affinity for other receptors noradrenergic or other neurotransmitter receptors or transporters. Preparation does not apply to the psychostimulants and is not derived from amphetamine. In clinical researches, there was an intensification of disease’s symptoms or of any adverse effects which are associated with the withdrawal syndrome. After oral intake Atomoxetine is almost quickly and completely absorbed. It has high affinity to plasma proteins, especially to albumin. Atomoxetine 10mg 180pills are distributed dosing forms nowadays. Medication undergoes first-pass metabolism, with the participation of isoenzyme. Statement of medicine is attention deficit hyperactivity disorder.
Atomoxetine drug’s applying
Attention deficit hyperactivity disorder (ADHD) in adolescents, adults, children 6 years of age and older, is the main drug’s indication for use. ADHD is a widespread condition among children aged older preschool and school age. The fact that disorder is not a debilitating disease, it is the name of etiologically heterogeneous group of disorders of behavior in children older than 5 years of age. These behavioral changes are accompanied by a violation of attention and also hyperactivity, potentially leading to school failure, anti-social behavior, decreased quality of life. Currently neurobiological nature of disease is studied, partially its pathogenesis is explored. A new medicine for ADHD treatment is Atomoxetine, the effect of which is based on pre-and postsynaptic modulation of dopamine and also norepinephrine at the receptor level, has been clinically tested. Adequate cure of ADHD (atomoxetine) helps to normalize the behavioral patterns of patients and their academic achievement. With age, the manifestations of disorder can be partially offset and transformed, without disappearing completely, even after reaching the age of majority.
Realizing forms and dosages Atomoxetine
Atomoxetine is released in 10mg, 18mg, 25mg and 40mg tablets form. Dose is taken inside without food or during a meal, as a single dosage in the morning. In case of adverse events while medicament’s taking one time by day, patients can recommend application twice per day. Children and also adolescents with a weight of body up to 70 kg use the initial dose 0.5 mg by kg a day and is increase to approximately 1,2 mg not sooner than three days. The advised maintenance dosage is about 1,2mg by kg and maximum daily is 1,8 mg per kg or 120 mg. In our chemist’s shop there is a big range of remedies including ADHD drugs.
Nonoperating effects Atomoxetine pills
Side effects in patients include insomnia, enuresis, bad mood, impaired sleep quality, tremor, fainting, early morning awakening, loss of appetite, mydriasis, nausea, conjunctivitis, abdominal pain, dry mouth, constipation, dyspepsia, insomnia, decreased libido, dizziness, palpitations, tachycardia, difficult urination, urinary retention, fatigue, weight loss, dermatitis, excessive sweating, dysmenorrhea, erectile dysfunction, hypersensitivity to preparation. With care must be applied in persons with hypertension, cardiovascular diseases, tachycardia. Atomoxetine can cause the arterial hypertension in individuals with end-stage chronic renal failure. In rare cases in patients receiving medicament marked allergic reaction – hives, angioedema, urticaria. Atomoxetine must not be assigned for about two weeks after MAO inhibitors discontinuation. In persons with moderate hepatic impairment starting and supporting a therapeutic dose is decreased to 50% of usual quantity. In patients with severely impaired hepatic function a starting and supporting amount should be reduced to 25% of the dosage.