Aventyl - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Nortriptyline hydrochloride
• Excipients: May include lactose, corn starch, magnesium stearate, colloidal silicon dioxide, and other inactive ingredients depending on the formulation.

• Capsules: Available in various strengths, including 10 mg, 25 mg, 50 mg, and 75 mg capsules.
• Oral Solution: Available as a liquid formulation, typically in 10 mg/5 mL concentration.

Aventyl belongs to the pharmacological group of tricyclic antidepressants (ATC code: N06AA10).

• Pharmacodynamics: Nortriptyline exerts its antidepressant effects by inhibiting the reuptake of norepinephrine and serotonin at the presynaptic neuronal membrane, thereby increasing their concentrations in the synaptic cleft. It also exhibits anticholinergic, antihistaminic, and alpha-adrenergic blocking properties.
• Pharmacokinetics: Following oral administration, nortriptyline is well-absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 4 to 8 hours. It undergoes extensive hepatic metabolism, primarily via the CYP2D6 enzyme pathway, and is excreted in the urine as metabolites.

Aventyl is indicated for the treatment of:

• Major depressive disorder
• Prophylactic management of chronic neuropathic pain
• Prophylactic management of tension-type headache

Aventyl is contraindicated in individuals with:

• Hypersensitivity to nortriptyline or any component of the formulation
• Recent myocardial infarction
• Severe cardiovascular disease
• Concurrent use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy

Nortriptyline may interact with other medications, including:

• Monoamine oxidase inhibitors (MAOIs)
• Selective serotonin reuptake inhibitors (SSRIs)
• Anticholinergic drugs
• CNS depressants
• Cimetidine

• Aventyl capsules should be taken orally once daily, preferably at bedtime, with or without food, as directed by a healthcare provider.
• The dosage and duration of therapy depend on the severity of the condition and individual patient response. Treatment should be initiated at a low dosage and titrated gradually to minimize side effects.
• For chronic neuropathic pain and tension-type headache, the recommended dosage is typically lower than that for depression.

• Aventyl should be used with caution during pregnancy, especially during the first trimester, and only if the potential benefits outweigh the potential risks to the fetus.
• Nortriptyline is excreted in breast milk, and breastfeeding is not recommended during Aventyl treatment.

• Dosage adjustments may be necessary in elderly patients and those with hepatic or renal impairment to prevent drug accumulation and minimize the risk of adverse effects.

In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of nortriptyline overdose may include drowsiness, confusion, hallucinations, seizures, and cardiac arrhythmias.

Common side effects of Aventyl may include:

• Dry mouth
• Constipation
• Blurred vision
• Urinary retention
• Dizziness
• Sedation

Aventyl capsules should be stored at controlled room temperature (20-25°C) in a dry place, protected from light and moisture. The expiration date should be checked before use.

These comprehensive instructions provide essential information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Aventyl, aiding healthcare professionals and patients in safe and effective medication use. Always consult a healthcare provider for personalized medical advice.