Celexa - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Citalopram hydrobromide
• Excipients: May include microcrystalline cellulose, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, and other inactive ingredients depending on the formulation.

• Tablets: Available in various strengths, including 10 mg, 20 mg, and 40 mg tablets.

Celexa belongs to the pharmacological group of selective serotonin reuptake inhibitors (SSRIs) (ATC code: N06AB04).

• Pharmacodynamics: Citalopram selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, leading to increased serotonin levels in synaptic clefts. This mechanism is thought to be responsible for its antidepressant effects.
• Pharmacokinetics: Citalopram is well-absorbed after oral administration, with peak plasma concentrations reached within 2 to 4 hours. It undergoes extensive hepatic metabolism via the cytochrome P450 enzyme system (primarily CYP2C19 and CYP3A4) and is primarily excreted in the urine.

Celexa is indicated for the treatment of:

• Major depressive disorder (MDD)
• Panic disorder with or without agoraphobia

Celexa is contraindicated in individuals with:

• Hypersensitivity to citalopram or any component of the formulation
• Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
• Known congenital long QT syndrome
• Concurrent use of pimozide or thioridazine
• Severe hepatic impairment

Citalopram may interact with other medications, including:

• MAOIs, serotonergic drugs, and other SSRIs, increasing the risk of serotonin syndrome
• Drugs that prolong the QT interval or inhibit CYP2C19 and CYP3A4 enzymes, potentially altering citalopram metabolism and efficacy
• CNS depressants, alcohol, and drugs that impair cognitive or motor function, potentiating sedation and impairment

• Celexa tablets should be taken orally once daily, with or without food, preferably in the morning or evening.
• The initial dosage for depression is typically 20 mg/day, with adjustments based on patient response and tolerability.
• For panic disorder, the initial dosage may be lower (10 mg/day), with gradual titration as needed.

• Celexa should be used with caution during pregnancy, especially during the third trimester, and only if the potential benefits outweigh the potential risks to the fetus.
• Citalopram is excreted in breast milk, and breastfeeding is not recommended during Celexa treatment due to the potential risk to the infant.

• Dosage adjustments may be necessary in patients with hepatic impairment or renal impairment to prevent drug accumulation and minimize the risk of adverse effects.
• Elderly patients may require lower initial doses and slower titration due to age-related changes in drug metabolism.

In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of citalopram overdose may include nausea, vomiting, dizziness, and QT interval prolongation.

Common side effects of Celexa may include:

• Nausea
• Dry mouth
• Fatigue
• Headache
• Insomnia
• Sexual dysfunction

Celexa tablets should be stored at controlled room temperature (20-25°C) in a dry place, protected from light and moisture. The expiration date should be checked before use.

These comprehensive instructions provide essential information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Celexa, aiding healthcare professionals and patients in safe and effective medication use. Always consult a healthcare provider for personalized medical advice.