Griseofulvin refers to the medical class of antibiotics with antifungal effects. This medication is very effective in relation of some fungi from the group of Epidermophyton, Microsporum and Trichophyton. The main active substance calls the distribution of fungous cells’ dividing in metaphase and protein synthesis from the damage of connections with matrix RNA. The fungi can accumulate in cells of skin, hair, nails and others. As far as possible the separation of infected keratin it happens its substitution for healthy tissue. Griseofulvin 250mg 90 pills are very widespread doses for the treatment of dermatomycosis, hair mycosis, epidermophytosis, nails mycosis, trichophytosis, onychomycosis favosa, crusted ringworm, microsporia of head’s hairy part, smooth skin microsporia, dermatomycosis of beard and moustaches, epidermophytosis of smooth skin, tinea pedis, ringworm of feet, epidermophytosis inguinalis, tinea cruris, eczema marginalis, onychomycosis, ringworm of nails and so on. The contra indications include hypersensitivity, porphyria, systemic lupus erythematosus, systemic sicknesses of blood, leucopenia, acute and subacute illnesses of liver and kidneys with different distributions of their functions, hepatic insufficiency, malignant neoplasms, several damages of cerebral blood circulation, some conditions after stroke, uterine bleeding, gestation, period of breast-feeding, child’s age till two years and others.