Mobic - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Meloxicam
- Excipients: May include lactose monohydrate, microcrystalline cellulose, crospovidone, povidone, sodium citrate dihydrate, magnesium stearate, colloidal silicon dioxide, and other inactive ingredients depending on the formulation.
Official Forms
- Mobic is available in various formulations, including:
- Tablets: Available in strengths such as 7.5 mg and 15 mg.
- Oral Suspension: Available in a concentration of 7.5 mg/5 mL.
Pharmacological Group
- Mobic belongs to the pharmacological group of nonsteroidal anti-inflammatory drugs (NSAIDs), specifically oxicams (ATC code: M01A B13).
Pharmacological Properties
- Pharmacodynamics: Meloxicam exhibits anti-inflammatory, analgesic, and antipyretic properties by inhibiting prostaglandin synthesis through selective inhibition of cyclooxygenase-2 (COX-2) enzyme activity. It primarily acts by reducing inflammation, pain, and fever associated with various conditions.
- Pharmacokinetics: Meloxicam is well-absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations achieved within 5-6 hours. It undergoes extensive hepatic metabolism via cytochrome P450 enzymes and is primarily excreted in the urine as metabolites.
Indications
- Mobic is indicated for the symptomatic relief of pain and inflammation in conditions such as:
- Osteoarthritis
- Rheumatoid arthritis
- Juvenile rheumatoid arthritis (in children aged 2 years and older)
Contraindications
- Mobic is contraindicated in individuals with:
- Hypersensitivity to meloxicam or any component of the formulation
- History of allergic reactions (e.g., asthma, urticaria, angioedema) to NSAIDs, including aspirin
- Active peptic ulcer disease or gastrointestinal bleeding
- Severe heart failure
- History of cerebrovascular bleeding or other bleeding disorders
- Severe renal impairment (creatinine clearance <30 mL/min)
- Severe hepatic impairment
- Pregnancy (third trimester)
- Concomitant use with other NSAIDs, including selective COX-2 inhibitors, due to the potential for additive adverse effects
Interactions
- Mobic may interact with various medications, including anticoagulants, antiplatelet agents, diuretics, ACE inhibitors, angiotensin II receptor blockers (ARBs), and selective serotonin reuptake inhibitors (SSRIs), potentially increasing the risk of gastrointestinal bleeding, renal toxicity, or cardiovascular events. Caution is advised when co-administering Mobic with these agents.
Specifics of Use
- Mobic tablets should be taken orally with a full glass of water, preferably with food to minimize gastrointestinal irritation. The dosage and duration of therapy depend on the severity of the condition and the patient’s response to treatment.
Pregnancy and Breastfeeding
- Mobic should be avoided during the third trimester of pregnancy due to the potential risk of premature closure of the fetal ductus arteriosus. It is not recommended for use during breastfeeding, as meloxicam may be excreted in human breast milk.
Impact on Motor Functions
- Mobic may cause dizziness, drowsiness, or visual disturbances. Patients should be cautious when driving or operating machinery until they know how Mobic affects them.
Dosage and Administration
- The recommended starting dose of Mobic for adults with osteoarthritis or rheumatoid arthritis is 7.5 mg once daily. The maximum daily dose should not exceed 15 mg.
- For children aged 2 years and older with juvenile rheumatoid arthritis, the recommended dose is based on body weight, not exceeding 0.125 mg/kg once daily.
Overdose
- In case of overdose, supportive measures should be initiated as needed. Symptoms of overdose may include nausea, vomiting, abdominal pain, dizziness, drowsiness, and gastrointestinal bleeding. Patients should seek medical attention if overdose is suspected.
Side Effects
- Common side effects of Mobic may include:
- Gastrointestinal disturbances (e.g., dyspepsia, abdominal pain, diarrhea)
- Headache
- Dizziness
- Edema
- Rash
- Serious adverse effects such as gastrointestinal ulceration, bleeding, renal impairment, cardiovascular events, and hepatotoxicity may occur rarely.
Storage and Shelf Life
- Mobic tablets and oral suspension should be stored at room temperature (20-25°C) in a dry place, protected from light and moisture. Check the expiration date on the packaging and discard any expired or unused medication.
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Aleve
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