Ocuflox - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Ofloxacin
• Excipients: May include benzalkonium chloride, sodium chloride, sodium hydroxide or hydrochloric acid (for pH adjustment), and purified water.

• Ophthalmic Solution: Available as a sterile solution containing ofloxacin in concentrations of 0.3%.

Ocuflox belongs to the pharmacological group of fluoroquinolone antibacterial agents (ATC code: S01AE01).

• Pharmacodynamics: Ofloxacin exerts its bactericidal effect by inhibiting bacterial DNA gyrase, preventing DNA replication and transcription, leading to cell death. It is active against a broad spectrum of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa.
• Pharmacokinetics: Following ocular administration, ofloxacin penetrates ocular tissues, achieving therapeutic concentrations in the aqueous humor, conjunctiva, and cornea. Minimal systemic absorption occurs, minimizing the risk of systemic side effects.

Ocuflox is indicated for the treatment of bacterial conjunctivitis caused by susceptible pathogens, including:

• Staphylococcus aureus
• Streptococcus pneumoniae
• Haemophilus influenzae
• Pseudomonas aeruginosa

Ocuflox is contraindicated in individuals with a history of hypersensitivity to ofloxacin or any component of the formulation, as well as those with a history of severe allergic reactions (e.g., anaphylaxis) to fluoroquinolone antibiotics.

Specifics of Use

• Ocuflox ophthalmic solution is for topical ophthalmic use only and should not be administered orally or parenterally.
• Contact lenses should be removed before instilling Ocuflox and may be reinserted 15 minutes after administration.
• The affected eye(s) should be cleansed with sterile saline solution before instillation to remove any discharge or debris.

• For bacterial conjunctivitis: Instill one to two drops of Ocuflox into the affected eye(s) every 2 to 4 hours for the first 2 days, followed by one to two drops every 4 to 6 hours for the next 5 days.
• Treatment duration should not exceed 7 days unless otherwise directed by a healthcare provider.

Common side effects of Ocuflox may include transient ocular burning or discomfort, blurred vision, itching, redness, and tearing. These side effects are usually mild and resolve with continued use.

Ocuflox ophthalmic solution should be stored at room temperature (15-30°C) in a dry place, protected from light. The bottle should be tightly closed when not in use. Once opened, the solution should be discarded after 28 days to prevent contamination.

There are limited data on the use of Ocuflox in pregnant or breastfeeding women. The potential benefits should be weighed against the potential risks to the fetus or infant. Consultation with a healthcare provider is recommended in these situations.

Ocuflox ophthalmic solution does not typically impair cognitive or motor functions. However, patients may experience transient blurred vision after administration, so caution is advised when driving or operating machinery.

Ocuflox is a valuable medication for the treatment of bacterial conjunctivitis, offering effective relief for ocular infections caused by susceptible pathogens. By understanding its mechanisms of action, indications, dosage, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes. Always consult a healthcare provider for personalized medical advice.