Priligy - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Dapoxetine hydrochloride
• Excipients: May include lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silica, magnesium stearate, hypromellose, titanium dioxide (E171), lactose monohydrate, triacetin, iron oxide black (E172), iron oxide yellow (E172), and other inactive ingredients depending on the formulation.

Tablets: Available in various strengths, including 30 mg and 60 mg tablets.

Priligy belongs to the pharmacological group of selective serotonin reuptake inhibitors (SSRIs) used for the treatment of premature ejaculation (PE) (ATC code: N06AX23).

• Pharmacodynamics: Dapoxetine selectively inhibits the reuptake of serotonin, thereby prolonging the time to ejaculation and improving control over ejaculation.
• Pharmacokinetics: After oral administration, dapoxetine is rapidly absorbed, with peak plasma concentrations achieved within 1 to 2 hours. It undergoes extensive hepatic metabolism and is excreted primarily in urine.

Priligy is indicated for the treatment of premature ejaculation in adult men aged 18 to 64 years.

Priligy is contraindicated in individuals with:

• Hypersensitivity to dapoxetine or any component of the formulation
• Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
• Significant cardiovascular conditions (e.g., heart failure, conduction abnormalities)

Dapoxetine may interact with various medications, including:

• MAOIs
• Serotonergic drugs (e.g., SSRIs, tricyclic antidepressants)
• Drugs metabolized by the CYP3A4 enzyme system (e.g., ketoconazole, erythromycin)
• Drugs that increase serotonin levels (e.g., triptans, tramadol)

• Priligy tablets should be taken orally as needed approximately 1 to 3 hours before anticipated sexual activity, with a full glass of water, with or without food.
• The recommended starting dose is 30 mg, with adjustments made based on individual response and tolerability, up to a maximum dose of 60 mg.
• Priligy is not intended for continuous daily use and should not be taken more than once every 24 hours.
• Treatment with Priligy should be initiated with caution in patients with underlying conditions predisposing to priapism (e.g., sickle cell anemia, leukemia, multiple myeloma).

Priligy is not indicated for use in women.

• The recommended starting dose of Priligy is 30 mg, taken as needed approximately 1 to 3 hours before anticipated sexual activity.
• Dosage adjustments may be necessary based on individual response and tolerability, up to a maximum dose of 60 mg.

In the event of Priligy overdose, supportive measures should be initiated, and symptomatic treatment may be necessary. Close monitoring of vital signs is essential.

Common side effects of Priligy may include:

• Nausea
• Headache
• Dizziness
• Insomnia
• Fatigue
• Diarrhea

Serious adverse effects such as syncope, seizures, and serotonin syndrome are rare but require immediate medical attention if they occur.

• Priligy tablets should be stored at room temperature (20-25°C) in a dry place, protected from light and moisture.

These comprehensive instructions provide valuable information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Priligy, facilitating safe and effective treatment of premature ejaculation. Always consult a healthcare professional for personalized medical advice.