Seromycin - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Cycloserine
• Excipients: May include corn starch, gelatin, magnesium stearate, talc, and other inactive ingredients depending on the formulation.

• Capsules: Available in various strengths, including 250 mg capsules.

Seromycin belongs to the pharmacological group of antibacterial agents, specifically second-line anti-tuberculosis drugs (ATC code: J04A A02).

• Pharmacodynamics: Cycloserine exerts its antibacterial effect by inhibiting cell wall synthesis in Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). It interferes with the formation of the bacterial cell wall, leading to cell lysis and death.
• Pharmacokinetics: Following oral administration, cycloserine is well-absorbed from the gastrointestinal tract. It is widely distributed in various body tissues and fluids, achieving therapeutic concentrations in the cerebrospinal fluid. Cycloserine is primarily excreted unchanged in the urine via renal filtration and tubular secretion.

Seromycin is indicated for the treatment of active tuberculosis (TB) caused by Mycobacterium tuberculosis strains that are resistant to first-line anti-tuberculosis medications or when first-line drugs cannot be tolerated.

Seromycin is contraindicated in individuals with a known hypersensitivity to cycloserine or any component of the formulation. It should not be used in patients with severe renal impairment or a history of epilepsy or psychiatric disorders.

Seromycin may interact with various medications, including certain anticonvulsants, antipsychotics, and antidepressants, potentially altering their efficacy or increasing the risk of adverse effects. Caution is advised when co-administering Seromycin with such drugs.

Seromycin capsules should be taken orally on an empty stomach, at least one hour before or two hours after meals, to enhance absorption. It is essential to follow the prescribed dosage and duration of therapy to ensure effective treatment.

The recommended dosage of Seromycin varies depending on the type and severity of tuberculosis, as well as patient characteristics such as weight, age, and renal function. Healthcare providers will determine the appropriate dose and treatment regimen based on clinical judgment and guidelines.

Common side effects of Seromycin may include dizziness, headache, drowsiness, nausea, vomiting, diarrhea, and allergic reactions. Serious adverse effects such as seizures, psychosis, and peripheral neuropathy are rare but require medical attention if they occur.

Seromycin capsules should be stored at room temperature (20-25°C) in a dry place, protected from light and moisture. They should be kept out of reach of children and pets.

Seromycin should be used with caution in pregnant or breastfeeding women, as safety data in these populations are limited. The potential benefits of treatment should be weighed against the potential risks to the fetus or infant.

Seromycin may cause dizziness or drowsiness in some individuals. Patients should exercise caution when driving or operating machinery, especially if they experience these side effects.

In the event of overdose, supportive measures should be initiated as needed. There is no specific antidote for cycloserine overdose, and treatment is primarily supportive.

Seromycin is a valuable medication for the treatment of drug-resistant tuberculosis, offering effective relief for patients who have failed first-line therapy. By understanding its mechanisms of action, indications, dosage, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes. Always consult a healthcare provider for personalized medical advice.