Strattera - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Atomoxetine hydrochloride
- Excipients: May include lactose monohydrate, pregelatinized starch, sodium lauryl sulfate, and other inactive ingredients depending on the formulation.
Official Forms
Capsules: Available in various strengths, including 10 mg, 18 mg, 25 mg, 40 mg, and 60 mg capsules.
Pharmacological Group
Strattera belongs to the pharmacological group of selective norepinephrine reuptake inhibitors (ATC code: N06BA09).
Pharmacological Properties
- Pharmacodynamics: Atomoxetine selectively inhibits the presynaptic norepinephrine transporter, increasing the extracellular concentration of norepinephrine in the prefrontal cortex, which helps improve attention and reduce hyperactivity and impulsivity.
- Pharmacokinetics: Following oral administration, atomoxetine is rapidly absorbed from the gastrointestinal tract. It undergoes extensive metabolism in the liver, primarily by the CYP2D6 enzyme pathway, and is eliminated mainly via renal excretion.
Indications
Strattera is indicated for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults.
Contraindications
Strattera is contraindicated in individuals with:
- Hypersensitivity to atomoxetine or any component of the formulation.
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy.
Interactions
Atomoxetine may interact with other medications, including:
- Drugs that inhibit or induce hepatic enzymes, potentially altering plasma concentrations of atomoxetine and other concomitant medications.
Specifics of Use
- Strattera capsules should be taken orally once or twice daily, with or without food, as directed by a healthcare provider.
- The dosage and duration of therapy depend on the patient’s age, weight, and response to treatment.
Pregnancy and Breastfeeding
- Strattera should be used with caution during pregnancy, especially in cases where the benefits outweigh the risks.
- It is excreted in breast milk, and breastfeeding is not recommended during Strattera treatment.
Dosage and Administration
Dosage adjustments may be necessary in patients with hepatic impairment or renal impairment to prevent drug accumulation and minimize the risk of adverse effects.
Overdose
In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of overdose may include tachycardia, hypertension, and seizures.
Side Effects
Common side effects of Strattera may include:
- Gastrointestinal disturbances (e.g., nausea, vomiting, constipation)
- Insomnia
- Decreased appetite
- Headache
Storage and Shelf Life
Strattera capsules should be stored at room temperature (15-30°C) in a dry place, protected from light and moisture. The expiration date should be checked before use.
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