Aleve - instructions, indications, composition, side effects

Active Ingredient: Naproxen Sodium

Excipients: May include microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, povidone, talc, and other inactive ingredients depending on the formulation.

Tablets: Available in various strengths, including 220 mg and 275 mg tablets.

Liquid Gels: Available in 220 mg strength.

Aleve belongs to the pharmacological group of nonsteroidal anti-inflammatory drugs (NSAIDs), specifically a derivative of propionic acid (ATC code: M01A E02).

Pharmacodynamics: Naproxen sodium exhibits anti-inflammatory, analgesic, and antipyretic effects by inhibiting the enzyme cyclooxygenase (COX), thereby reducing the synthesis of prostaglandins involved in pain and inflammation.

Pharmacokinetics: Following oral administration, naproxen sodium is rapidly absorbed from the gastrointestinal tract. It undergoes extensive metabolism in the liver and is primarily eliminated through urinary excretion.

Aleve is indicated for the relief of:

• Mild to moderate pain (e.g., headache, toothache, menstrual cramps)
• Musculoskeletal conditions (e.g., osteoarthritis, rheumatoid arthritis)
• Acute gout
• Fever

Aleve is contraindicated in individuals with a history of hypersensitivity to naproxen or other NSAIDs, as well as those with a history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It should not be used in patients with active peptic ulcer disease, severe heart failure, or renal impairment.

Aleve may interact with other medications, including anticoagulants, antiplatelet drugs, diuretics, ACE inhibitors, and lithium, potentially increasing the risk of bleeding or adverse effects. Caution is advised when co-administering Aleve with other drugs.

Aleve tablets or liquid gels should be taken orally with a full glass of water. The dosage and duration of therapy should be individualized based on the patient’s condition, response to treatment, and risk factors for adverse effects. It is recommended to take Aleve with food or milk to reduce the risk of gastrointestinal irritation.

Aleve is not recommended during the third trimester of pregnancy due to the potential risk of fetal harm, including premature closure of the ductus arteriosus. It should be avoided in breastfeeding women, as it may be excreted in breast milk and could harm the nursing infant.

Aleve may cause dizziness or drowsiness in some patients. Therefore, caution is advised when driving or operating machinery, especially during the initiation of therapy or following dosage adjustments.

The recommended dosage of Aleve varies depending on the indication, severity of pain, and patient factors. Healthcare providers will determine the appropriate dose and treatment duration based on clinical judgment and guidelines.

In the event of an overdose, supportive measures should be initiated as needed. Aleve overdoses may lead to symptoms such as gastrointestinal irritation, nausea, vomiting, and renal impairment. Immediate medical attention is required in cases of overdose.

Common side effects of Aleve may include gastrointestinal disturbances (e.g., dyspepsia, abdominal pain), headache, dizziness, and rash. Serious adverse effects such as gastrointestinal bleeding, cardiovascular events, and renal impairment are rare but may occur, especially with prolonged use or at high doses.

Aleve tablets and liquid gels should be stored at room temperature (15-30°C) in a dry place, protected from light and moisture. Keep out of reach of children. Check the expiration date on the packaging and discard any expired or unused medication.

These extended instructions provide comprehensive information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, storage, and usage of Aleve, aiding healthcare professionals and patients in safe and effective pain management. Always consult a healthcare provider for personalized medical advice.