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Buy Combigan online without prescription in Worldwide Pharmacies
Combigan belongs to the combined medicamental remedies containing of two main active substances brimonidine and timolol, which are capable of lowering elevated intraocular pressure by mutual enhancing effect, which contributes to a more pronounced hypotensive action. Eye drops are applied to cure following pathologies as ocular hypertension, wide-angle glaucoma. The medicament is chiefly recommended in case if the effectiveness of local beta adrenergic blocker is not sufficient. The recommended dosage for adults including the elderly is one drop twice a day about every twelve hours, may be in the morning and evening. If the patient needs to employ more than one drop of ophthalmic medicines, the next dose should be carried out at intervals of not less than 5 minutes. People just order Combigan 5ml 6 bottles online with best price. As all eye drops, to decrease possible systemic absorption, it is advised the compression of lacrimal sac from medial part (blockage of the lacrimal points) for one minute. This must be done immediately after the instillation of each of eye drops. The main contra indications are respiratory sicknesses such as bronchial asthma, bronchitis, bradycardia, cardiogenic shock, heart failure, use in neonates, people taking antidepressants, monoamine oxidase with the action of noradrenergic transmission. During the application of product you may experience conjunctival hyperemia, pain and a burning sensation in the eyes, itching, allergic conjunctivitis, blepharitis, blurred vision, tearing, corneal erosion, eye pain, irritation. It is necessary to pass medical examination before you buy Combigan online without a prescription.
Generic name: Brimonidine/Timolol
Brand name: Combigan
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Combigan - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
Active Ingredients: Brimonidine tartrate, Timolol maleate
Excipients: May include benzalkonium chloride, purified water, sodium chloride, and other inactive ingredients depending on the formulation.
Official Forms
Eye Drops: Available in various concentrations, including 0.2% brimonidine tartrate and 0.5% timolol maleate.
Pharmacological Group
Combigan belongs to the pharmacological group of alpha-2 adrenergic agonists and beta-blockers (ATC code: S01ED51).
Pharmacological Properties
- Pharmacodynamics: Brimonidine tartrate lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Timolol maleate reduces intraocular pressure by decreasing aqueous humor secretion.
- Pharmacokinetics: Brimonidine and timolol are absorbed systemically after ocular administration. Peak plasma concentrations are reached within hours. They undergo hepatic metabolism and renal excretion.
Indications
Combigan is indicated for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to monotherapy with either brimonidine or timolol.
Contraindications
Combigan is contraindicated in individuals with:
- Hypersensitivity to brimonidine, timolol, or any component of the formulation.
- Severe pulmonary disease (e.g., bronchial asthma, chronic obstructive pulmonary disease).
- Severe sinus bradycardia, second- or third-degree atrioventricular block, overt cardiac failure, cardiogenic shock.
Interactions
Combigan may interact with other medications, including:
- Monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, or other central nervous system depressants, potentially leading to additive effects on the central nervous system.
- Beta-blockers, calcium channel blockers, or cardiac glycosides, potentially increasing the risk of bradycardia or heart block.
Specifics of Use
- Combigan eye drops should be instilled into the affected eye(s) according to the prescribed dosage regimen.
- Shake the bottle well before each use and avoid touching the dropper tip to any surface to prevent contamination.
- Contact lenses should be removed before administration and may be reinserted after 15 minutes.
Pregnancy and Breastfeeding
- Combigan should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus.
- It is not recommended during breastfeeding due to limited data on its excretion into breast milk.
Dosage and Administration
The recommended dosage is one drop of Combigan in the affected eye(s) twice daily, approximately 12 hours apart.
Overdose
In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of overdose may include systemic side effects such as hypotension, bradycardia, and central nervous system depression.
Side Effects
Common side effects of Combigan may include:
- Ocular irritation (e.g., burning, stinging, itching)
- Conjunctival hyperemia (redness)
- Blurred vision
- Dry mouth
- Fatigue
- Headache
Less common but more severe adverse reactions may include:
- Allergic reactions (e.g., rash, itching, swelling)
- Conjunctival follicles
- Conjunctival hemorrhage
- Corneal erosion
- Corneal infiltrates
- Dizziness
- Dyspnea
- Eye discharge
- Eye pain
- Foreign body sensation
- Hypersensitivity reactions (e.g., bronchospasm, anaphylaxis)
- Photophobia
- Visual disturbances
If any of these side effects persist or worsen, patients should discontinue use and consult their healthcare provider promptly. Additionally, patients should seek medical attention if they experience any signs of systemic absorption, such as changes in heart rate, blood pressure, or mental status.
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