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Isordil is one of the main antianginal (anti-ischemic) organic nitrates for peroral (over the mouth) applying. The main active substance is Isosorbide dinitrate. This matter possess by antianginal and vasodilating action. The drug increases the containing of nitrogen oxide in vessels endothelium. The remedy possesses by some behavior mainly of venous and also arterial dilatator. Isordil 10mg 180 pills are the main doses for the whole course of medical cure. This medicamental agent is broadly allocated in view of antianginal remedy under the chronic flowing of heart’s ishemic sickness for preventive measures for stenocardia attacks; under the infrequent attacks of stable stenocardia of tension. During the last several years this medicant is successfully employed in view of peripheral vasodilator (the remedy broadened the vessels’ clear space) under the heaviest forms of cardiac insufficiency. This preparation diminishes the venous blood supply to the heart, pressure in vessels of lesser circle, short breathing, asphyxia or asthma and cyanosis. Sometimes this medicament is assigned under the endarteritis (inflammation of arteries’ inside cover) and some other sicknesses accompanied by some spasms of peripheral vessels. Nowadays more and more patients buy Isordil online with help of our informational portal without any prescriptions. You can also order the delivery all over the country.
Generic name: Isosorbide dinitrate
Brand name: Isordil, Dilatrate-SR, Nitrosorbid, Izodinit, Cornilate, Lomilan, Armadan, Carvizine, Corodil, Coronex, Izotrat, Metronitrone, Vazocardine
Isordil: Your Comprehensive Guide to Angina Treatment
Welcome to our comprehensive guide on Isordil, a medication primarily used for the treatment of angina pectoris (chest pain). Whether you’re a healthcare professional seeking detailed information or a patient looking to better understand your treatment options, this guide will provide valuable insights into Isordil’s mechanisms of action, indications, dosage, potential side effects, precautions, and more.
Introduction to Isordil
Isordil, also known by its generic name isosorbide dinitrate, belongs to a class of medications called nitrates. It works by dilating blood vessels, increasing blood flow to the heart, and reducing the workload on the heart. Isordil is available in various formulations, including tablets and sublingual tablets, providing flexibility in dosing and administration.
How Isordil Works
Isordil exerts its therapeutic effects by releasing nitric oxide, a potent vasodilator, in the blood vessels. Nitric oxide relaxes and widens blood vessels, allowing more oxygen-rich blood to flow to the heart muscle. By increasing coronary blood flow, Isordil helps relieve angina symptoms such as chest pain, pressure, or tightness.
Indications for Use
Isordil is indicated for the prevention and treatment of angina pectoris due to coronary artery disease. It may be used as monotherapy or in combination with other anti-anginal medications, such as beta-blockers or calcium channel blockers, for optimal symptom control.
Buy Isordil without Prescription: While Isordil is typically available by prescription only, some online pharmacies may offer it for sale without the need for a prescription. However, it’s essential to ensure that you’re purchasing from a reputable source to guarantee product quality and safety.
Dosage and Administration
The dosage of Isordil varies depending on the severity of angina symptoms, the patient’s response to treatment, and the formulation used. Isordil tablets are typically taken orally, with or without food, and may be administered two to three times daily. Sublingual tablets are placed under the tongue for rapid absorption and quick relief of acute angina symptoms.
Potential Side Effects
Common side effects of Isordil may include headache, dizziness, lightheadedness, flushing, and hypotension (low blood pressure). These side effects are usually mild and transient, but patients should notify their healthcare provider if they persist or worsen over time.
Precautions and Warnings
Isordil should be used with caution in patients with hypotension, volume depletion, or severe anemia, as it may further lower blood pressure. It is contraindicated in patients with acute circulatory failure or shock and those with a known hypersensitivity to nitrates or nitric oxide donors.
Conclusion
Isordil is a valuable medication for the treatment of angina, offering effective symptom relief and improved quality of life for patients with coronary artery disease. When used appropriately and under the guidance of a healthcare professional, Isordil can help alleviate chest pain and reduce the frequency and severity of angina episodes. By understanding Isordil’s mechanisms of action, indications, dosage, and precautions, healthcare professionals and patients can work together to achieve optimal angina management outcomes.
Isordil - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Isosorbide dinitrate
- Excipients: May include lactose monohydrate, microcrystalline cellulose, maize starch, colloidal anhydrous silica, magnesium stearate, and other inactive ingredients depending on the formulation.
Official Forms
- Isordil is available in various formulations, including:
- Tablets: Available in strengths such as 5 mg and 10 mg.
- Sublingual tablets: Available in strengths such as 2.5 mg and 5 mg.
- Extended-release tablets: Available in strengths such as 40 mg.
- Oral spray: Available in strengths such as 1.25 mg per spray.
Pharmacological Group
- Isordil belongs to the pharmacological group of organic nitrates and nitrites (ATC code: C01D A08).
Pharmacological Properties
- Pharmacodynamics: Isosorbide dinitrate is a vasodilator that relaxes smooth muscles in blood vessels, leading to vasodilation and decreased cardiac preload and afterload. It primarily acts by releasing nitric oxide, which activates guanylate cyclase, resulting in increased cyclic guanosine monophosphate (cGMP) levels and smooth muscle relaxation.
- Pharmacokinetics: Isosorbide dinitrate is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver to active metabolites. It has a short half-life of about 1 to 4 hours and is primarily excreted in the urine.
Indications
- Isordil is indicated for the prevention and treatment of angina pectoris (chest pain) due to coronary artery disease. It may also be used in the management of congestive heart failure and acute myocardial infarction (heart attack).
Contraindications
- Isordil is contraindicated in individuals with:
- Hypersensitivity to isosorbide dinitrate or any component of the formulation
- Severe anemia
- Hypotension (low blood pressure)
- Circulatory shock
- Increased intracranial pressure
- Concomitant use with phosphodiesterase-5 (PDE-5) inhibitors such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra) due to the risk of severe hypotension
- Concomitant use with riociguat, a soluble guanylate cyclase stimulator, due to the risk of hypotension
- Acute myocardial infarction associated with marked hypotension or volume depletion
Interactions
- Isordil may interact with various medications, including other vasodilators, antihypertensive agents, calcium channel blockers, beta-blockers, tricyclic antidepressants, and alcohol, potentially increasing the risk of hypotension or other cardiovascular effects. Caution is advised when co-administering Isordil with these agents.
Specifics of Use
- Isordil tablets should be taken orally with a full glass of water, preferably on an empty stomach. Sublingual tablets should be placed under the tongue and allowed to dissolve completely. The dosage and frequency of administration depend on the patient’s condition and response to therapy.
Pregnancy and Breastfeeding
- Isordil may be used during pregnancy if the potential benefits outweigh the potential risks to the fetus. However, caution is advised, and the lowest effective dose should be used. It is not known whether Isordil is excreted in human breast milk, so breastfeeding mothers should consult a healthcare professional before using Isordil.
Impact on Motor Functions
- Isordil may cause dizziness or lightheadedness, especially when standing up suddenly from a sitting or lying position. Patients should avoid driving or operating machinery until they know how Isordil affects them.
Dosage and Administration
- The recommended dosage of Isordil varies depending on the formulation and the patient’s condition. For the prevention of angina, the usual starting dose of oral Isordil tablets is 5 mg to 20 mg three to four times daily. Sublingual Isordil tablets are used for the acute relief of angina symptoms, with doses ranging from 2.5 mg to 5 mg as needed.
Overdose
- In case of overdose, supportive measures should be initiated as needed. Symptoms of overdose may include severe hypotension, syncope (fainting), dizziness, headache, and methemoglobinemia. Patients should seek medical attention if overdose is suspected.
Side Effects
- Common side effects of Isordil may include:
- Headache
- Dizziness
- Flushing (warmth, redness, or tingling sensation)
- Hypotension
- Tachycardia (rapid heartbeat)
- Nausea or vomiting
- Serious adverse effects such as methemoglobinemia, rebound angina, and tolerance may occur with long-term use or at high doses.
Storage and Shelf Life
- Isordil should be stored at room temperature (15-30°C) in a dry place, protected from light and moisture. Check the expiration date on the packaging and discard any expired or unused medication.