Rulide - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Roxithromycin
• Excipients: May include lactose, microcrystalline cellulose, povidone, croscarmellose sodium, magnesium stearate, hypromellose, macrogol, and titanium dioxide depending on the formulation.

• Tablets: Available in various strengths, including 150 mg and 300 mg tablets.

Rulide belongs to the pharmacological group of macrolide antibiotics (ATC code: J01F A09).

• Pharmacodynamics: Roxithromycin exerts its antibacterial effect by inhibiting bacterial protein synthesis, thereby preventing bacterial growth and replication. It is active against a wide range of Gram-positive and Gram-negative bacteria, as well as atypical pathogens.
• Pharmacokinetics: Following oral administration, roxithromycin is rapidly absorbed from the gastrointestinal tract. It is distributed widely in various body tissues and fluids, achieving therapeutic concentrations in respiratory, urinary, and soft tissue infections. Roxithromycin is primarily metabolized in the liver and excreted in the bile and urine.

Rulide is indicated for the treatment of various bacterial infections caused by susceptible pathogens, including:

• Upper respiratory tract infections (e.g., tonsillitis, pharyngitis, sinusitis)
• Lower respiratory tract infections (e.g., bronchitis, pneumonia)
• Skin and soft tissue infections
• Genitourinary tract infections (e.g., urethritis, cervicitis)
• Sexually transmitted infections (e.g., chlamydia)
• Helicobacter pylori eradication in combination therapy for peptic ulcer disease

Rulide is contraindicated in individuals with a known hypersensitivity to roxithromycin, other macrolide antibiotics, or any component of the formulation. It should not be used in patients with severe hepatic impairment or a history of cholestatic jaundice associated with macrolide use.

Rulide may interact with various medications, including ergot alkaloids, warfarin, theophylline, digoxin, and certain antifungal agents. Caution is advised when co-administering Rulide with such drugs, as it may alter their pharmacokinetics or increase the risk of adverse effects.

Rulide tablets should be taken orally with or without food, preferably at evenly spaced intervals throughout the day, and swallowed whole with a full glass of water. The dosage and duration of therapy depend on the type and severity of the infection, as well as patient factors such as age and renal function.

The recommended dosage of Rulide varies depending on the indication, severity of the infection, and patient characteristics. Healthcare providers will determine the appropriate dose and treatment duration based on clinical judgment and guidelines.

Common side effects of Rulide may include gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea, abdominal pain), headache, dizziness, and allergic reactions. Serious adverse effects such as hepatotoxicity and QT prolongation are rare but require medical attention if they occur.

Rulide tablets should be stored at room temperature (15-25°C) in a dry place, protected from light and moisture. They should be kept out of reach of children and pets.

Rulide should be used with caution in pregnant or breastfeeding women, as safety data in these populations are limited. The potential benefits of treatment should be weighed against the potential risks to the fetus or infant.

Rulide does not typically impair cognitive or motor functions. However, patients should be cautious when driving or operating machinery, especially if they experience dizziness or other central nervous system side effects.

In the event of overdose, supportive measures should be initiated as needed. Roxithromycin overdoses are rarely associated with severe toxicity. Hemodialysis is not effective in removing roxithromycin from the bloodstream due to its high protein binding and extensive tissue distribution.

Rulide is a valuable medication for the treatment of bacterial infections, offering effective relief for a wide range of respiratory, skin, and genitourinary tract infections. By understanding its mechanisms of action, indications, dosage, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes. Always consult a healthcare provider for personalized medical advice.