Suprax - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Cefixime (as Cefixime trihydrate)
• Excipients: May include microcrystalline cellulose, sodium starch glycolate, magnesium stearate, and other inactive ingredients depending on the formulation.

• Tablets: Available in various strengths, typically in 200 mg tablets.
• Oral Suspension: Available as a powder for reconstitution into an oral suspension, typically in 100 mg/5 mL and 200 mg/5 mL concentrations.

Suprax belongs to the pharmacological group of antibacterial agents, specifically third-generation cephalosporins (ATC code: J01D D08).

• Pharmacodynamics: Cefixime exerts its antimicrobial effect by inhibiting bacterial cell wall synthesis, leading to cell death. It is active against a broad spectrum of Gram-positive and Gram-negative bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
• Pharmacokinetics: Following oral administration, cefixime is well-absorbed from the gastrointestinal tract. It is distributed widely in various body tissues and fluids, achieving therapeutic concentrations in the respiratory tract and urinary tract. Cefixime is primarily excreted unchanged in the urine via renal filtration and tubular secretion.

Suprax is indicated for the treatment of various infections caused by susceptible pathogens, including:

• Upper respiratory tract infections (e.g., otitis media, pharyngitis)
• Lower respiratory tract infections (e.g., bronchitis)
• Urinary tract infections
• Uncomplicated gonorrhea
• Uncomplicated cervical and urethral gonorrhea caused by susceptible Neisseria gonorrhoeae

Suprax is contraindicated in individuals with a known hypersensitivity to cephalosporins or any component of the formulation. It should not be used in patients with a history of severe allergic reactions (e.g., anaphylaxis) to beta-lactam antibiotics.

Suprax may interact with various medications, including antacids, probenecid, and other antibiotics, potentially altering their efficacy or increasing the risk of adverse effects. Caution is advised when co-administering Suprax with such drugs.

Suprax tablets should be taken orally with a full glass of water, preferably with meals, to enhance absorption and minimize gastrointestinal side effects. The oral suspension should be reconstituted according to the instructions provided before administration.

The recommended dosage of Suprax varies depending on the type and severity of the infection, as well as patient factors such as age, weight, and renal function. Healthcare providers will determine the appropriate dose and duration of therapy based on clinical judgment and guidelines.

Common side effects of Suprax may include gastrointestinal disturbances (e.g., diarrhea, nausea, abdominal pain), headache, and allergic reactions. Serious adverse effects such as pseudomembranous colitis and anaphylaxis are rare but require medical attention if they occur.

Suprax tablets and oral suspension should be stored at room temperature (15-30°C) in a dry place, protected from light and moisture. Once reconstituted, the oral suspension should be refrigerated and discarded after the specified time period (usually 7-14 days).

Suprax is generally considered safe for use during pregnancy and breastfeeding. However, caution is advised, and the potential benefits should outweigh the potential risks to the fetus or infant. Consultation with a healthcare provider is recommended in these situations.

Suprax does not typically impair cognitive or motor functions. However, patients should be cautious when driving or operating machinery, especially if they experience dizziness or other central nervous system side effects.

In the event of overdose, supportive measures should be initiated as needed. Cefixime overdoses are rarely associated with severe toxicity.

Suprax is an important antibiotic for the treatment of various bacterial infections. By understanding its mechanisms of action, indications, dosage, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes. Always consult a healthcare provider for personalized medical advice.