By the results of clinical applying the side effects are systematized by the organs and systems and frequency of appearance. By the frequency of appearance all collateral results are divided into very often (≥ 1 on 10), often (≥ 1 on 100 and <1 on 10), not often (≥ 1 on 1000 and <1 on 100), seldom (≥ 1 on 10000 and <1 on 1000), very seldom <(1 on 10000), unknown (by having data the frequency is impossible to define).
The frequent side effects are different reactions from the side of gastrointestinal tract and central nervous system. They appear approximately by 5-30% of patients applied Tramadol in the therapeutical dosages.
The undesirable effects which are appeared and manifested in more than 5% patients are dizziness, nausea, constipation, headaches, sleepiness, vomiting, itching, asthenia, hyperhidrosis, breathlessness, dryness in mouth and diarrhea.
From the side of the central nervous system*
Very often: dizziness, headaches.
Often: taste discomposing, memory damages, nervousness, agitation, anxiety, myoclonus, dystonia, migraine, tremor.
Not often: disorders of the attention concentration, vertigo, acathisia, dysarthria.
Seldom: convulsions, damages of ECG.
Very seldom: dystonia, ataxia, parkinsonism, disorders of the movements’ coordination, memory discomposing, paresthesia, fainting fit.
Unknown: coma, delirium, damages of the apprehensibility, dyskinesia.
From the side of gastrointestinal tract*
Very seldom: heightening of the hepatic ferments’ level, jaundice, hepatitis.
Not often: toothaches, gums irritation.
Very often: dryness in mouth, gastrointestinal disorders including nausea and vomiting.
Often: some pains in stomach, constipation, dyspepsia.
Unknown: perforation of the bowels.
From the side of immune system*
Often: the reaction of hypersensibility such as nettle rush.
Very seldom: more heavy reaction of hypersensibility including the angioneurotic edema, breathlessness / bronchial spasm or anaphylactic shock.
Arthralgia, myalgia and fever are also appeared in connection with some precipitation and other symptoms of hypersensibility with moderated type. These symptoms can remind the serum sickness.
From the side of visual organs*
Often: visual disorders.
Not often: mydriasis, diplopia.
Unknown: heightening of eyes pressure.
From the side of hearing organs*
Often: ringing in the ears.
From the side of heart*
Seldom: myocardial infarction.
Very seldom: the strongest palpitation.
Not often: tachycardia, damages of the cardiac rhythm, some changes of ECG.
Unknown: heightening of the arterial pressure, edemas.
From the side of vessels*
Often: heightening of the arterial pressure (in some case it can be considerable one), reddening.
Very seldom: vasodilation, orthostatic hypotension.
From the side of metabolism and disorders of digestion*
Not often: body weight decreasing. If the body weight decreasing is the largest symptom of patient’s depression it is followed to take into account such potentials of Wellbutrin SR as anorexia and / or body weight decreasing.
Very seldom: discomposing of the glucose level on blood.
From the side of psychics*
Often: excitation, stimulation, anxiety, insomnia.
Not often: depression, dysphoria, random orientation.
Very seldom: aggression, hostility, irritability, uneasiness, hallucinations, unusual dreams, depersonalization, delirium, paranoid thoughts.
Frequency is unknown: suicidal ideas and suicidal behavior, psychosis.
Unknown: sleeping damages, euphoria, mania, hypomania, some exchanges of the psychical condition.
From the side of skin and hypodermic tissue*
Often: precipitation, itching, hyperhidrosis.
Very often: polymorphous erythema, Stevens-Johnson syndrome, psoriasis sharpening.
From the side of respiratory system*
Seldom: bronchitis, pulmonary embolism.
From the side of locomotive apparatus and connecting tissues*
Very seldom: vellication or muscle convulsions.
Often: arthritis, arthrosis.
From the side of kidneys and urogenital system*
Often: libido lowering, infections of the urogenital system.
Very seldom: increasing of the urination frequency and / or its delay.
Unknown: erectile dysfunction, damages of the menstrual cycle, gynecomastia, testicles edema, glycosuria, nocturia.
Often: weight loss, increasing of muscles tonus, swallowing damages, weight loss, fever, some pains in breast, asthenia.
From the side of blood*
Unknown: leukocytosis, leukocytopenia, thrombocytopenia.