Ilosone - Comprehensive Usage Guide: instructions, indications, composition, side effects

• Active Ingredient: Erythromycin
• Excipients: May include lactose, magnesium stearate, corn starch, and other inactive ingredients depending on the formulation.

• Tablets: Available in various strengths, including 250 mg and 500 mg tablets.
• Suspension: Available as a liquid formulation, typically in 125 mg/5 mL and 250 mg/5 mL concentrations.

Ilosone belongs to the pharmacological group of macrolide antibiotics (ATC code: J01FA01).

• Pharmacodynamics: Erythromycin exerts its bacteriostatic effects by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis.
• Pharmacokinetics: Following oral administration, erythromycin is rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 1 to 2 hours. It is metabolized in the liver and excreted primarily in the bile.

Ilosone is indicated for the treatment of various bacterial infections, including respiratory tract infections, skin and soft tissue infections, and sexually transmitted diseases.

Ilosone is contraindicated in individuals with:

• Known hypersensitivity to erythromycin or any component of the formulation.
• Concomitant use of drugs metabolized by the cytochrome P450 system, particularly CYP3A4 substrates.
• History of cholestatic jaundice/hepatic dysfunction associated with prior use of erythromycin.

Erythromycin may interact with other medications, including:

• Drugs metabolized by the cytochrome P450 system, leading to altered plasma concentrations and potential toxicity or reduced efficacy.

• Ilosone tablets or suspension should be taken orally with or without food, as directed by a healthcare provider.
• The dosage and duration of therapy depend on the type and severity of the infection, as well as patient factors such as age and renal function.

• Ilosone should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus.
• It is excreted in breast milk, so breastfeeding is not recommended during treatment with Ilosone.

• Dosage adjustments may be necessary in patients with hepatic impairment to prevent drug accumulation and minimize the risk of adverse effects.

In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of overdose may include nausea, vomiting, and diarrhea.

Common side effects of Ilosone may include:

• Gastrointestinal disturbances (e.g., nausea, abdominal pain, diarrhea)
• Allergic reactions (e.g., rash, pruritus, urticaria)
• Transient hearing loss (rare)

Ilosone tablets and suspension should be stored at controlled room temperature (20-25°C) in a dry place, protected from light and moisture. The expiration date should be checked before use.

These comprehensive instructions provide essential information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Ilosone, aiding healthcare professionals and patients in safe and effective medication use. Always consult a healthcare provider for personalized medical advice.