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Generic name: Paxil CR
Brand name: Paroxetinum
Introduction to Paxil CR
Paxil CR, also known by its generic name paroxetine controlled-release, belongs to a class of medications called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the levels of serotonin, a neurotransmitter in the brain that regulates mood, emotions, and behavior. Paxil CR is primarily used to alleviate symptoms of depression, generalized anxiety disorder (GAD), panic disorder, social anxiety disorder (SAD), and post-traumatic stress disorder (PTSD).
How Paxil CR Works
Paxil CR exerts its therapeutic effects by selectively inhibiting the reuptake of serotonin in the brain, thereby prolonging its action at the synaptic junctions between nerve cells. By enhancing serotonin neurotransmission, Paxil CR helps alleviate symptoms of depression and anxiety and improves overall mood and well-being.
Indications for Use
Paxil CR is indicated for the treatment of:
- Major Depressive Disorder (MDD)
- Generalized Anxiety Disorder (GAD)
- Panic Disorder (PD)
- Social Anxiety Disorder (SAD)
- Post-Traumatic Stress Disorder (PTSD)
- Obsessive-Compulsive Disorder (OCD)
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Dosage and Administration
The dosage of Paxil CR varies depending on the condition being treated, the patient’s age, and individual response to treatment. For depression and anxiety disorders, the typical starting dose is 12.5 mg taken orally once daily in the morning, with or without food. The dosage may be adjusted by a healthcare provider based on the patient’s response and tolerability.
Potential Side Effects
Common side effects of Paxil CR may include:
- Nausea
- Drowsiness or fatigue
- Dry mouth
- Headache
- Insomnia
- Sexual dysfunction These side effects are usually mild and transient but should be reported to a healthcare provider if they persist or worsen over time. Serious side effects such as suicidal thoughts, serotonin syndrome, or allergic reactions require immediate medical attention.
Precautions and Warnings
Paxil CR should be used with caution in patients with a history of seizures, bipolar disorder, or bleeding disorders. It may interact with other medications, including monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), and anticoagulants, potentially increasing the risk of adverse effects or altering drug levels in the blood.
Overdose and Emergency Management
In cases of Paxil CR overdose, immediate medical attention is necessary. Symptoms of overdose may include dizziness, tremors, seizures, and cardiac arrhythmias. Treatment may involve supportive measures, gastric lavage, and administration of activated charcoal.
Conclusion
Paxil CR is an effective treatment option for depression, anxiety disorders, and related conditions, helping alleviate symptoms and improve quality of life for patients. Online pharmacies offer convenient access to this medication, but it’s crucial to adhere to proper dosage guidelines, monitor for potential side effects, and seek medical advice if needed. By understanding Paxil CR’s pharmacology, indications, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes.
Paxil CR - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Paroxetine hydrochloride
- Excipients: May include dibasic calcium phosphate dihydrate, hypromellose, magnesium stearate, polyethylene glycols, sodium starch glycolate, titanium dioxide, and other inactive ingredients depending on the formulation.
Official Forms
- Controlled-Release Tablets: Available in various strengths, including 12.5 mg, 25 mg, and 37.5 mg.
Pharmacological Group
Paxil CR belongs to the pharmacological group of selective serotonin reuptake inhibitors (SSRIs) used for the treatment of depressive disorders, panic disorder, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder (PTSD) (ATC code: N06AB05).
Pharmacological Properties
- Pharmacodynamics: Paroxetine selectively inhibits the reuptake of serotonin, leading to increased serotonin levels in the synaptic cleft. This mechanism is thought to contribute to its antidepressant and anxiolytic effects.
- Pharmacokinetics: Paroxetine is well-absorbed after oral administration, with peak plasma concentrations achieved within 4 to 6 hours. It undergoes extensive hepatic metabolism and has an elimination half-life of approximately 21 hours.
Indications
Paxil CR is indicated for the treatment of:
- Major depressive disorder
- Panic disorder
- Social anxiety disorder (social phobia)
- Generalized anxiety disorder (GAD)
- Post-traumatic stress disorder (PTSD)
Contraindications
Paxil CR is contraindicated in individuals with:
- Hypersensitivity to paroxetine or any component of the formulation
- Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
- Severe hepatic impairment
Interactions
Paroxetine may interact with various medications, including:
- MAOIs
- Serotonergic drugs (e.g., SSRIs, tricyclic antidepressants)
- Warfarin and other drugs metabolized by cytochrome P450 enzymes
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Tamoxifen
Specifics of Use
- Paxil CR tablets should be taken orally once daily in the morning, with or without food.
- The tablets should be swallowed whole and not chewed, crushed, or broken, as this may affect the controlled-release mechanism.
- Treatment with Paxil CR should be initiated at the lowest effective dose, with dosage adjustments made based on individual response and tolerability.
Pregnancy and Breastfeeding
Paxil CR should be used with caution during pregnancy, especially during the first trimester, and only if the potential benefits outweigh the potential risks to the fetus. It is excreted in breast milk, and breastfeeding is not recommended during Paxil CR treatment due to the potential for adverse effects in the nursing infant.
Dosage and Administration
- The recommended starting dose of Paxil CR for most indications is 25 mg once daily.
- Dosage adjustments may be necessary based on individual response and tolerability, up to a maximum dose of 62.5 mg once daily.
Overdose
In the event of Paxil CR overdose, supportive measures should be initiated, and symptomatic treatment may be necessary. Close monitoring of vital signs is essential.
Side Effects
Common side effects of Paxil CR may include:
- Nausea
- Headache
- Dizziness
- Somnolence
- Insomnia
- Dry mouth
Serious adverse effects such as serotonin syndrome, suicidal ideation, and withdrawal symptoms are rare but require immediate medical attention if they occur.
Storage and Shelf Life
- Paxil CR tablets should be stored at room temperature (20-25°C) in a dry place, protected from light and moisture.
These comprehensive instructions provide valuable information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Paxil CR, facilitating safe and effective treatment of depressive and anxiety disorders. Always consult a healthcare professional for personalized medical advice.