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Maxalt relates to the powerful medicamental agents well-known as pain-killers. This medication possesses by anti migraine action. The main active substance of this drug is Rizatriptan Benzoate. It is a selective agonist of the 5-HT-receptors. Thanks to its stimulating activity on these receptors this remedy renders an antimigrainous effect. This preparation is metabolized under some taking part of MAO inhibitors of the A type. Maxalt 10mg 52 pills are generally taken for the medical cure, some pains relieving or once-only cutting off the migraine and migraine attacks with aura or without it. This medicant isn’t practically applied if the patient has one or more of these diseases such as decompensated arterial hypertension; ascertained coronary heart sickness including stenocardia, cardiac infarction in anamnesis, documented clinically unsuspected coronary heart illness; suspicion on the coronary heart sickness; Prinzmetal’s angina; simultaneous therapy or period less then two weeks after treatment stopping by MAO inhibitors; heightened apprehensibility to the main active matter and some others. This drug also cannot be employed by those patients who have basilar severe headaches, hemiplegic hemicephalalgia, under the non-typical for migraine headache, pregnancy, lactation, child’s age and different others.
Generic name: Rizatriptan
Brand name: Maxalt, Rizalt, Rizaliv
Maxalt: Your Comprehensive Guide to Migraine Relief
Welcome to our comprehensive guide on Maxalt, a medication primarily used for the treatment of migraine headaches. Whether you’re a healthcare professional seeking detailed information or a patient looking to better understand your treatment options, this guide will provide valuable insights into Maxalt’s mechanisms of action, indications, dosage, potential side effects, precautions, and more.
Introduction to Maxalt
Maxalt, also known by its generic name rizatriptan, belongs to a class of medications called triptans. It works by narrowing blood vessels in the brain and reducing the release of certain natural substances that cause migraine symptoms. Maxalt is available in various formulations, including tablets and orally disintegrating tablets, providing flexibility in dosing and administration.
How Maxalt Works
Maxalt exerts its therapeutic effects by binding to serotonin receptors in the brain, which helps reduce inflammation and relieve pain associated with migraines. By constricting blood vessels and inhibiting the release of inflammatory mediators, Maxalt helps alleviate migraine symptoms such as headache, nausea, sensitivity to light and sound, and visual disturbances.
Indications for Use
Maxalt is indicated for the acute treatment of migraine attacks with or without aura in adults. It is not intended for the prevention of migraines or the treatment of cluster headaches. Maxalt should be used as soon as migraine symptoms appear, for the best chance of relief.
Buy Maxalt without Prescription: While Maxalt is typically available by prescription only, some online pharmacies may offer it for sale without the need for a prescription. However, it’s essential to ensure that you’re purchasing from a reputable source to guarantee product quality and safety.
Dosage and Administration
The dosage of Maxalt varies depending on the severity of migraine symptoms and the patient’s response to treatment. Maxalt tablets are typically taken orally, with or without food, and should be swallowed whole with water. Orally disintegrating tablets can be placed on the tongue, where they dissolve quickly without the need for water. Patients should follow the dosing instructions provided by their healthcare provider.
Potential Side Effects
Common side effects of Maxalt may include dizziness, drowsiness, fatigue, dry mouth, and chest pain or tightness. These side effects are usually mild and transient, but patients should notify their healthcare provider if they persist or worsen over time. Maxalt may also cause a temporary increase in blood pressure, especially in patients with uncontrolled hypertension.
Precautions and Warnings
Maxalt should be used with caution in patients with certain medical conditions, such as coronary artery disease, uncontrolled hypertension, or liver or kidney impairment. It is contraindicated in patients with ischemic heart disease, Prinzmetal’s angina, or a history of stroke or transient ischemic attack (TIA). Maxalt should not be used concomitantly with ergotamine or other 5-HT1 agonists.
Conclusion
Maxalt is a valuable medication for the acute treatment of migraine headaches, offering rapid and effective relief for migraine sufferers. When used appropriately and under the guidance of a healthcare professional, Maxalt can help alleviate migraine symptoms and improve patients’ quality of life. By understanding Maxalt’s mechanisms of action, indications, dosage, and precautions, healthcare professionals and patients can work together to achieve optimal migraine management outcomes.
Maxalt - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Rizatriptan benzoate
- Excipients: May include microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, hypromellose, triacetin, titanium dioxide (E171), and other inactive ingredients depending on the formulation.
Official Forms
- Maxalt is available in various formulations, including:
- Tablets: Available in strengths such as 5 mg and 10 mg.
Pharmacological Group
- Maxalt belongs to the pharmacological group of selective serotonin 5-HT1 receptor agonists (triptans) (ATC code: N02C C04).
Pharmacological Properties
- Pharmacodynamics: Rizatriptan is a selective agonist for serotonin (5-HT1B and 5-HT1D) receptors. Its primary action is to cause vasoconstriction of cranial arteries and inhibition of neuropeptide release, resulting in the relief of migraine headache.
- Pharmacokinetics: Rizatriptan is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-1.5 hours after oral administration. It undergoes extensive hepatic metabolism via monoamine oxidase (MAO) and cytochrome P450 enzymes. The elimination half-life is approximately 2-3 hours.
Indications
- Maxalt is indicated for the acute treatment of migraine attacks with or without aura in adults. It is not intended for the prophylactic therapy of migraine or for the treatment of cluster headaches.
Contraindications
- Maxalt is contraindicated in individuals with:
- Hypersensitivity to rizatriptan or any component of the formulation
- Ischemic heart disease (e.g., angina pectoris, history of myocardial infarction)
- Prinzmetal’s angina
- Peripheral vascular disease
- Uncontrolled hypertension
- History of stroke or transient ischemic attack (TIA)
- Severe hepatic impairment
- Concomitant use with ergotamine derivatives or other 5-HT1 receptor agonists
- Concomitant use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOIs
Interactions
- Maxalt may interact with various medications, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), MAOIs, ergotamine derivatives, and other triptans, potentially increasing the risk of serotonin syndrome or other adverse effects. Caution is advised when co-administering Maxalt with these agents.
Specifics of Use
- Maxalt tablets should be taken orally with a full glass of water, preferably as soon as migraine symptoms appear. The dosage and frequency of administration depend on the severity of the migraine and the patient’s response to therapy.
Pregnancy and Breastfeeding
- Maxalt should be used during pregnancy only if the potential benefits justify the potential risks to the fetus. It is not recommended for use during breastfeeding, as rizatriptan may be excreted in human breast milk.
Impact on Motor Functions
- Maxalt may cause dizziness or drowsiness. Patients should be cautious when driving or operating machinery until they know how Maxalt affects them.
Dosage and Administration
- The recommended starting dose of Maxalt is 5 mg, taken as soon as migraine symptoms appear. If migraine relief is not achieved, a second dose may be taken after at least 2 hours, not exceeding a total daily dose of 30 mg.
- For patients with hepatic impairment or mild to moderate renal impairment, a lower starting dose of 5 mg is recommended.
Overdose
- In case of overdose, supportive measures should be initiated as needed. Symptoms of overdose may include serotonin syndrome, chest pain, bradycardia, hypertension, and central nervous system depression. Patients should seek medical attention if overdose is suspected.
Side Effects
- Common side effects of Maxalt may include:
- Dizziness
- Fatigue
- Somnolence
- Nausea
- Dry mouth
- Chest pain or tightness
- Palpitations
- Serious adverse effects such as myocardial ischemia, myocardial infarction, ventricular tachycardia, and transient ischemic attack (TIA) may occur rarely.
Storage and Shelf Life
- Maxalt should be stored at room temperature (25°C) in a dry place, protected from light and moisture. Check the expiration date on the packaging and discard any expired or unused medication.