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Celexa belongs to strong antidepressant agents. The action’s mechanism involves a reverse neuronal selective blockade of serotonin at synapses with neurons of CNS with minimum effect against reuptake of norepinephrine and dopamine. Celexa helps to improve mood, relieves anxiety, reduces fear and stress, eliminates dysphoria, reduces OCD, practically does not invoke sedation. Stable clinical effect develops after 7-10 days of regular use. After oral administration Cmax of Celexa in plasma is achieved in 2-4 hours. Bioavailability at intake is about 80%. Changes in plasma medicament’s concentrations are linear. In plasma remedy is mostly unchanged, metabolized by demethylation, oxidation, deamination. Celexa 10mg 90 pills are the more distributed dosing form. Medication is excreted by kidneys and through the intestines. The medicine’s assignment is treatment of depressions. Patients are allowable to buy celexa online during all day.
Generic name: Citalopram.
Brand name: Celapram, Cipramil, Ciazil.
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The main Celexa application is depressions of various origins (endogenous and exogenous), affective (depression, bipolar, dysthymic) disorder, mixed anxiety-depressive disorder; anxiety and phobic disorders like panic disorders, obsessive-compulsive, generalized anxiety, somatization disorder, psychosomatic disease with autonomic dysfunction (including the respiratory system, gastrointestinal tract, cardiovascular system, urogenital system, vascular dementia with depressive symptoms, depressive disorders in women as premenstrual dysphoria, depression during pregnancy, postpartum depression, depression in premenopausal), eating disorders (anorexia, bulimia), depression in alcoholism, depression in the elderly. Nowadays you can buy Celexa without prescription overnight delivery.
Where can I buy Celexa without prescription online USA? Realizing forms and dosages
Dose form of medicament is 10mg, 20mg, 40mg. Order celexa right now and here. The recommended daily amount for depressions, OCD is 20 mg once per day. According to individual patient’s response to treatment and disease severity the maximum dosage is 60 mg per day. For panic disorders it is advised to use daily 10 mg Celexa once a day for the first therapy week, after which it was raised to 20 mg. Patients with mild or possible moderate renal impairment may use the preparation in conventional doses. Information about treatment with Celexa in individuals with severe renal insufficiency is not available. Typically an antidepressant drug action is observed after about 2-4 weeks of cure. Therapy with antidepressants is symptomatic and must be held for a long time. In the case of people with periodic (recurrent) depression supportive cure should be carried out for several years to prevent the onset of disease following phases. Where can I buy Celexa without prescription online USA? People may purchase preparations always all day here.
If you want cheap Celexa without a prescription it is essential to know warning and nonoperating effects
Side effects of Celexa include:
-the nervous system: headache, tremor, dizziness, somnolence, agitation, headache, nervousness, paresthesia, sleep disturbance, amnesia, anxiety, increased appetite, impaired concentration, decreased libido, anorexia, apathy, suicidal attempts, confusion , fatigue, mood changes, aggressive behavior, agitation, mania, panic behavior, hypomania, paranoid reaction, extreme tiredness, restlessness, psychosis, convulsions, euphoria, hallucinations, serotonin syndrome, depersonalization;
-the cardio-vascular system: atrial fibrillation, tachycardia, increased or possible decreased blood pressure, orthostatic hypotension, ventricular arrhythmias;
-the digestive system: constipation, nausea, dyspepsia, dry mouth, diarrhea, vomiting, flatulence, anorexia, abdominal pain, increased salivation, increased liver enzymes;
-the urinary system: polyuria, frequent urination;
-the metabolic disorders: decreased or increased body mass index, hyponatremia, hyperthermia;
-the respiratory system: rhinitis, shortness of breath, sinusitis, cough;
-the reproductive system: abnormal ejaculation, female anorgasmia, dysmenorrhea, impotence, menstrual irregularities, galactorrhea;
-skin: rash, itching, increased sweating, sensitivity to light, epidermal necrolysis, angioedema;
-the musculoskeletal system: myalgia, arthralgia;
-other: asthenia, fatigue, allergic reactions, syncope, malaise, mammalgia, yawning, teeth grinding.
Contraindications are hypersensibility to Celexa. Simultaneous use with MAO inhibitors is contra-indicated within 14 days after the termination of their admission. Order and buy cheap Celexa without a prescription in chemist’s shop.
Celexa - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Citalopram hydrobromide
- Excipients: May include microcrystalline cellulose, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, and other inactive ingredients depending on the formulation.
Official Forms
- Tablets: Available in various strengths, including 10 mg, 20 mg, and 40 mg tablets.
Pharmacological Group
Celexa belongs to the pharmacological group of selective serotonin reuptake inhibitors (SSRIs) (ATC code: N06AB04).
Pharmacological Properties
- Pharmacodynamics: Citalopram selectively inhibits the reuptake of serotonin (5-HT) in the central nervous system, leading to increased serotonin levels in synaptic clefts. This mechanism is thought to be responsible for its antidepressant effects.
- Pharmacokinetics: Citalopram is well-absorbed after oral administration, with peak plasma concentrations reached within 2 to 4 hours. It undergoes extensive hepatic metabolism via the cytochrome P450 enzyme system (primarily CYP2C19 and CYP3A4) and is primarily excreted in the urine.
Indications
Celexa is indicated for the treatment of:
- Major depressive disorder (MDD)
- Panic disorder with or without agoraphobia
Contraindications
Celexa is contraindicated in individuals with:
- Hypersensitivity to citalopram or any component of the formulation
- Concomitant use of monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
- Known congenital long QT syndrome
- Concurrent use of pimozide or thioridazine
- Severe hepatic impairment
Interactions
Citalopram may interact with other medications, including:
- MAOIs, serotonergic drugs, and other SSRIs, increasing the risk of serotonin syndrome
- Drugs that prolong the QT interval or inhibit CYP2C19 and CYP3A4 enzymes, potentially altering citalopram metabolism and efficacy
- CNS depressants, alcohol, and drugs that impair cognitive or motor function, potentiating sedation and impairment
Specifics of Use
- Celexa tablets should be taken orally once daily, with or without food, preferably in the morning or evening.
- The initial dosage for depression is typically 20 mg/day, with adjustments based on patient response and tolerability.
- For panic disorder, the initial dosage may be lower (10 mg/day), with gradual titration as needed.
Pregnancy and Breastfeeding
- Celexa should be used with caution during pregnancy, especially during the third trimester, and only if the potential benefits outweigh the potential risks to the fetus.
- Citalopram is excreted in breast milk, and breastfeeding is not recommended during Celexa treatment due to the potential risk to the infant.
Dosage and Administration
- Dosage adjustments may be necessary in patients with hepatic impairment or renal impairment to prevent drug accumulation and minimize the risk of adverse effects.
- Elderly patients may require lower initial doses and slower titration due to age-related changes in drug metabolism.
Overdose
In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of citalopram overdose may include nausea, vomiting, dizziness, and QT interval prolongation.
Side Effects
Common side effects of Celexa may include:
- Nausea
- Dry mouth
- Fatigue
- Headache
- Insomnia
- Sexual dysfunction
Storage and Shelf Life
Celexa tablets should be stored at controlled room temperature (20-25°C) in a dry place, protected from light and moisture. The expiration date should be checked before use.
These comprehensive instructions provide essential information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Celexa, aiding healthcare professionals and patients in safe and effective medication use. Always consult a healthcare provider for personalized medical advice.