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Pristiq refers to the medical group of anti depressed agents (antidepressants) well-known as SNRIs (serotonin-norepinephrine reuptake inhibitors). The main active matter is Desvenlafaxine. This substance inhibits the reverse capture of dopamine in insignificant degree. The mechanism of this matter’s action is made conditional by capability to find antilogarithm of nervous impulses’ transmission to the central nervous system. Pristiq 100mg 90 pills are generally taken for treating of depression’s all kinds, different depressed conditions and episodes, panic distressing factors, generalized anxious derangements, social anxious discomposure (or social phobia) and many others. Before you buy Pristiq online and then apply these medcines you need to visit your psychiatrist and say him if you take MAO inhibitors, have some illnesses of kidneys and liver, high arterial pressure, some convulsions or epilepsy, bipolar disarray (maniacal depression), bipolar disorder or self-destruction in family anamnesis or suicidal ideas and others. You also should say to your physician if you cannot employ this medication or you need a dosage correction and special observing during the therapeutic course. The symptoms of overdose are dizziness, insomnia, vomiting, nausea, dumbness or pricking in extremities and so on. You also can buy other antidepressants pharmacy online in any time you want. But you cannot take Pristiq together with other anti depressed preparations, powerful antibiotics and anti anxious medicaments.
Generic name: Desvenlafaxine
Brand name: Pristiq, D-Veniz, Efexor, Effexor
Introduction to Pristiq
Pristiq, with the generic name desvenlafaxine, belongs to a class of medications known as serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by increasing the levels of serotonin and norepinephrine, two neurotransmitters in the brain associated with mood regulation. Pristiq is primarily used to alleviate symptoms of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
How Pristiq Works
Pristiq exerts its therapeutic effects by selectively inhibiting the reuptake of serotonin and norepinephrine in the brain, thereby prolonging their action at the synaptic junctions between nerve cells. By enhancing the activity of these neurotransmitters, Pristiq helps alleviate symptoms of depression and anxiety and improve overall mood and well-being.
Indications for Use
Pristiq is indicated for the treatment of:
- Major Depressive Disorder (MDD)
- Generalized Anxiety Disorder (GAD)
Where to Buy Pristiq Online Without Prescription: For those seeking to purchase Pristiq online without a prescription, reputable internet pharmacies offer comprehensive information on the medication, including dosage instructions, potential side effects, and contraindications. Overnight delivery options may be available for added convenience.
Dosage and Administration
The dosage of Pristiq varies depending on the condition being treated, the patient’s age, and individual response to treatment. For MDD, the typical starting dose is 50 mg taken orally once daily, with or without food. For GAD, the recommended starting dose is also 50 mg daily, with the option to increase to 100 mg daily based on clinical response.
Potential Side Effects
Common side effects of Pristiq may include:
- Nausea
- Dizziness
- Dry mouth
- Insomnia
- Headache
- Constipation These side effects are usually mild and transient but should be reported to a healthcare provider if they persist or worsen over time. Serious side effects such as suicidal thoughts, serotonin syndrome, or allergic reactions require immediate medical attention.
Precautions and Warnings
Pristiq should be used with caution in patients with a history of seizures, bipolar disorder, or bleeding disorders. It may interact with other medications, including monoamine oxidase inhibitors (MAOIs), SSRIs, and SNRIs, potentially increasing the risk of adverse effects or altering drug levels in the blood.
Overdose and Emergency Management
In cases of Pristiq overdose, immediate medical attention is necessary. Symptoms of overdose may include nausea, vomiting, dizziness, and elevated blood pressure. Treatment may involve supportive measures, gastric lavage, and administration of activated charcoal.
Conclusion
Pristiq is an effective treatment option for depression and anxiety disorders, helping alleviate symptoms and improve quality of life for patients. Online pharmacies offer convenient access to this medication, but it’s crucial to adhere to proper dosage guidelines, monitor for potential side effects, and seek medical advice if needed. By understanding Pristiq’s pharmacology, indications, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes.
Pristiq - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Desvenlafaxine succinate
- Excipients: May include microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate, hypromellose, edetate disodium, and other inactive ingredients depending on the formulation.
Official Forms
Extended-Release Tablets: Available in various strengths, including 25 mg, 50 mg, and 100 mg tablets.
Pharmacological Group
Pristiq belongs to the pharmacological group of serotonin-norepinephrine reuptake inhibitors (SNRIs) (ATC code: N06AX23).
Pharmacological Properties
- Pharmacodynamics: Desvenlafaxine selectively inhibits the reuptake of serotonin and norepinephrine in the central nervous system, thereby enhancing neurotransmission and exerting antidepressant effects.
- Pharmacokinetics: After oral administration, desvenlafaxine is rapidly absorbed, with peak plasma concentrations achieved within 4 hours. It undergoes extensive hepatic metabolism via the cytochrome P450 enzyme system and is excreted primarily in urine.
Indications
Pristiq is indicated for the treatment of:
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
Contraindications
Pristiq is contraindicated in individuals with:
- Hypersensitivity to desvenlafaxine or any component of the formulation
- Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy
Interactions
Desvenlafaxine may interact with various medications, including:
- MAOIs
- Serotonergic drugs (e.g., SSRIs, tricyclic antidepressants)
- Drugs metabolized by the CYP3A4 enzyme system (e.g., ketoconazole, erythromycin)
- Drugs that increase serotonin levels (e.g., triptans, tramadol)
Specifics of Use
- Pristiq tablets should be taken orally once daily with or without food, swallowed whole and not divided, crushed, chewed, or dissolved.
- The dosage should be individualized based on the patient’s response and tolerance, with initial doses typically lower for certain populations (e.g., elderly patients, patients with hepatic impairment).
- Gradual dose titration may be necessary to minimize the risk of adverse effects.
- It may take several weeks for the full therapeutic effect of Pristiq to be achieved, and treatment should be continued even if symptomatic improvement is observed.
Pregnancy and Breastfeeding
- Pristiq should be used with caution during pregnancy, especially during the third trimester, due to the potential risk of neonatal complications such as persistent pulmonary hypertension of the newborn (PPHN).
- Breastfeeding is not recommended during Pristiq treatment due to the excretion of desvenlafaxine and its metabolites in breast milk.
Dosage and Administration
- The recommended starting dose for MDD and GAD is 50 mg/day, with adjustments made based on clinical response and tolerability, up to a maximum dose of 100 mg/day.
- Dosage adjustments may be necessary in patients with renal impairment to prevent drug accumulation and minimize the risk of adverse effects.
Overdose
In the event of Pristiq overdose, supportive measures should be initiated, and symptomatic treatment may be necessary. Close monitoring of vital signs and cardiac function is essential.
Side Effects
Common side effects of Pristiq may include:
- Nausea
- Headache
- Dizziness
- Insomnia
- Dry mouth
- Constipation
Serious adverse effects such as serotonin syndrome, suicidal ideation, and hypertensive crisis are rare but require immediate medical attention if they occur.
Storage and Shelf Life
- Pristiq tablets should be stored at room temperature (20-25°C) in a dry place, protected from light and moisture.
These comprehensive instructions provide valuable information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of Pristiq, facilitating safe and effective antidepressant therapy. Always consult a healthcare professional for personalized medical advice.