- Choose dosage:
- × 2mg
Buy Tizanidine online without prescription in Worldwide Pharmacies
Tizanidine covers to the medicamental group of muscle relaxants with powerful effect. This drug possesses by central and muscle relaxing action. The main active matter excites the alpha2-adrenergic receptors mainly on the level of spinal brain. This substance brings down the emission of excited amino acids from the intermediate neurons of spinal brain; selectively oppresses the polysynaptic mechanisms answered for the muscular hyper tonus. The remedy relaxes the skeletal musculature under the chronic spastic conditions of spinal and cerebral origin; removes acute painful muscular spasms and clonic convulsions. The medication lowers the muscles resistance under the passive movements and heightens the power of unconditioned muscular reductions. Tizanidine 4mg 90 pills are chiefly indicated for the medical cure of painful muscular spasms under the sicknesses of backbone (including osteochondrosis, spondylosis, vertebral ankylosis, syringomyelia, Morvan’s illness, hemiplegia, cervical and lumbar syndromes), after surgical operations by the way of herniation of intervertebral disk or thigh osteoarthrosis, spasticity and pains conditioned by several neurologic sicknesses: multiple sclerosis, chronic myelopathy, degenerative diseases of spinal brain, some damages of cerebral blood circulation, stroke, craniocerebral injuries, cerebral palsy, convulsions of central origin and so on. You can buy Tizanidine online at the lowest prices in the best pharmacies all over the country with twenty-four-hour delivery.
Generic name: Tizanidine
Brand name: Sirdalud, Zanaflex
Tizanidine - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Tizanidine hydrochloride
- Excipients: May include microcrystalline cellulose, silicon dioxide, stearic acid, and other inactive ingredients depending on the formulation.
Official Forms
- Tablets: Available in various strengths, including 2 mg and 4 mg tablets.
- Capsules: Available in 2 mg, 4 mg, and 6 mg capsules.
Pharmacological Group
Tizanidine belongs to the pharmacological group of centrally acting alpha-2 adrenergic agonists (ATC code: M03BX02).
Pharmacological Properties
- Pharmacodynamics: Tizanidine acts centrally by stimulating alpha-2 adrenergic receptors, leading to inhibition of spinal motor neurons and reduction of muscle tone. It is indicated for the management of spasticity.
- Pharmacokinetics: Following oral administration, tizanidine is rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1 to 2 hours. It undergoes extensive hepatic metabolism and is primarily excreted in the urine as metabolites.
Indications
Tizanidine is indicated for the management of spasticity associated with conditions such as multiple sclerosis, spinal cord injury, and cerebral palsy.
Contraindications
Tizanidine is contraindicated in individuals with:
- Hypersensitivity to tizanidine or any component of the formulation.
- Severe hepatic impairment.
- Concurrent use of potent CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin).
Interactions
Tizanidine may interact with other medications, including:
- Potent CYP1A2 inhibitors, potentially increasing tizanidine concentrations and the risk of adverse effects.
- Drugs with sedative effects, such as alcohol and benzodiazepines, leading to additive CNS depression.
Specifics of Use
- Tizanidine tablets or capsules should be taken orally with or without food, as directed by a healthcare provider.
- The dosage and frequency of administration should be individualized based on the patient’s response and tolerance to the medication.
Pregnancy and Breastfeeding
- Tizanidine should be used with caution during pregnancy, especially during the first trimester, and only if the potential benefits outweigh the risks.
- It is excreted in breast milk, so breastfeeding is not recommended during treatment with tizanidine.
Dosage and Administration
- Dosage adjustments may be necessary in patients with renal or hepatic impairment to avoid drug accumulation and potential toxicity.
Overdose
In case of overdose, supportive measures should be initiated, and medical attention should be sought immediately. Symptoms of overdose may include drowsiness, hypotension, and respiratory depression.
Side Effects
Common side effects of tizanidine may include:
- Drowsiness
- Dry mouth
- Dizziness
- Weakness
- Hypotension
Storage and Shelf Life
Tizanidine tablets and capsules should be stored at controlled room temperature (20-25°C) in a dry place, protected from light and moisture. The expiration date should be checked before use.
These comprehensive instructions provide essential information on the composition, pharmacological properties, indications, contraindications, interactions, administration, side effects, and storage of tizanidine, aiding healthcare professionals and patients in safe and effective medication use. Always consult a healthcare provider for personalized medical advice.
Sevelamer
Chloroquine
