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Xifaxan covers to the medical agents well-known as antibiotics with action’s broad spectrum from the group of ansamicins. The main active substance is Rifaximin mainly applied for the treatment of intestinal infections. This preparation is very active against several gram-positive (salmonella, shigella, Friedlander’s bacillus, proteus, yersinia, enterobacteria and some others) and gram-negative bacteria (streptococcus, enterococcus, staphylococcus, clostridia, peptostreptococcus). Under the using inward this dug practically isn’t absorbed in blood that’s why it creates the highest concentrations of active matter in clear space of bowels. Xifaxan 400mg 90 pills suppress the pathogenic intestinal flora, destroy the bacteria in diverticula (saccule visible formations), a portion of the large intestine, so bringing down the inflammation under the diverticular disease. The main matter also lowers the formations by bacteria of toxic commissures that prevents the development of hepatic encephalopathy under the liver’s lesions. The preparation is chiefly taken under the acute intestinal infections called by some bacteria which are very apprehensible to this remedy including diarrhea of travelers, chronic colitis, and diverticular disease of colon, hepatic encephalopathy and other. This medical agent is also employed under the syndrome of redundant growth of bacteria in bowels. As preventive measure this medication is taken under the surgical operations on the large intestine and rectum. Buy Xifaxan online at the lowest price with help of our informational service.
Generic name: Rifaximin
Brand name: Xifaxan, Rifacol, Colidur, Normix, Zaxine, Spiraxin.
Xifaxan: Your Comprehensive Guide to Antibiotic Treatment
Welcome to our detailed guide on Xifaxan, a potent antibiotic used in the management of bacterial infections. Whether you’re a healthcare professional seeking in-depth insights or a patient exploring treatment options, this comprehensive overview will provide you with valuable information regarding Xifaxan’s mechanisms of action, indications, dosage, potential side effects, precautions, and more.
Introduction to Xifaxan
Xifaxan, also known as Rifaximin, is a broad-spectrum antibiotic renowned for its efficacy against a variety of bacterial infections. It belongs to the rifamycin class of antibiotics and is widely prescribed for the treatment of gastrointestinal conditions caused by bacteria. Xifaxan is particularly effective against Gram-positive and Gram-negative bacteria, making it a versatile option for combating infections of the gut.
How Xifaxan Works
Xifaxan exerts its antibacterial effects by inhibiting bacterial RNA synthesis. It achieves this by binding to the beta-subunit of bacterial RNA polymerase, thereby blocking the transcription of bacterial DNA into RNA. This disruption in RNA synthesis impairs bacterial protein production, ultimately leading to bacterial growth inhibition and cell death.
Indications for Use
Xifaxan is indicated for the treatment of various gastrointestinal conditions, including travelers’ diarrhea caused by noninvasive strains of Escherichia coli, irritable bowel syndrome with diarrhea (IBS-D) in adults, and hepatic encephalopathy. Additionally, Xifaxan may be used off-label for the treatment of small intestinal bacterial overgrowth (SIBO) and other gastrointestinal disorders.
Buy Xifaxan without Prescription: While Xifaxan is typically available by prescription only, it’s essential to consult a healthcare professional before use to ensure accurate diagnosis and appropriate antibiotic therapy.
Dosage and Administration
The dosage of Xifaxan may vary depending on the specific gastrointestinal condition being treated, as well as the patient’s age, weight, and renal function. It is usually administered orally in the form of tablets or sachets, with or without food. The recommended dosage and duration of treatment will be determined by the healthcare provider based on the individual patient’s needs.
Potential Side Effects
Common side effects of Xifaxan may include gastrointestinal symptoms such as nausea, vomiting, abdominal pain, bloating, and flatulence. Additionally, Xifaxan may cause headaches, dizziness, and changes in bowel habits. Patients should promptly report any adverse reactions to their healthcare provider for further evaluation.
Precautions and Warnings
Xifaxan should be used with caution in patients with a history of liver disease or hepatic encephalopathy, as well as in pregnant or breastfeeding women. It may interact with certain medications, including P-glycoprotein inhibitors and drugs metabolized by cytochrome P450 enzymes, potentially altering their efficacy or increasing the risk of side effects. Xifaxan is contraindicated in individuals with a known hypersensitivity to rifamycin antibiotics.
Conclusion
Xifaxan is a valuable antibiotic with broad-spectrum activity and efficacy in the treatment of various gastrointestinal conditions. By understanding Xifaxan’s mechanisms of action, indications, dosage, and precautions, patients and healthcare providers can collaborate to achieve optimal treatment outcomes and effectively combat bacterial infections of the gut. With appropriate use and adherence to treatment regimens, Xifaxan stands as a cornerstone in the management of gastrointestinal disorders, promoting gastrointestinal health and overall well-being.
Xifaxan - Comprehensive Usage Guide: instructions, indications, composition, side effects
Composition
- Active Ingredient: Rifaximin
- Excipients: May include microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and other inactive ingredients depending on the formulation.
Official Forms
- Tablets: Available in various strengths, typically in 200 mg tablets.
Pharmacological Group
Xifaxan belongs to the pharmacological group of antibiotics, specifically rifamycins (ATC code: A07AA11).
Pharmacological Properties
- Pharmacodynamics: Rifaximin exerts its bactericidal effect by inhibiting bacterial RNA synthesis, thereby disrupting protein synthesis and leading to bacterial cell death. It exhibits broad-spectrum activity against Gram-positive and Gram-negative bacteria, including Escherichia coli and other enteric pathogens.
- Pharmacokinetics: Following oral administration, rifaximin is poorly absorbed from the gastrointestinal tract, resulting in high concentrations in the intestinal lumen. It has minimal systemic absorption, reducing the risk of systemic side effects. Rifaximin is excreted unchanged in the feces, with minimal renal elimination.
Indications
Xifaxan is indicated for the treatment of various gastrointestinal conditions, including:
- Traveler’s diarrhea caused by noninvasive strains of Escherichia coli
- Irritable bowel syndrome with diarrhea (IBS-D) in adults
Contraindications
Xifaxan is contraindicated in individuals with a known hypersensitivity to rifaximin or any component of the formulation. It should not be used in patients with a history of severe hepatic impairment.
Interactions
Xifaxan may interact with certain medications, including P-glycoprotein inhibitors (e.g., cyclosporine), potentially increasing rifaximin levels in the body. Caution is advised when co-administering Xifaxan with such drugs.
Specifics of Use
Xifaxan tablets should be taken orally with or without food, preferably at evenly spaced intervals throughout the day, and swallowed whole with a full glass of water.
Dosage and Administration
The recommended dosage of Xifaxan for traveler’s diarrhea is 200 mg three times daily for 3 days. For IBS-D, the recommended dosage is 550 mg once daily for 14 days. Dosage adjustments are not required in patients with renal impairment.
Side Effects
Common side effects of Xifaxan may include nausea, abdominal pain, flatulence, and headache. Serious adverse effects such as Clostridium difficile-associated diarrhea and hypersensitivity reactions are rare but require medical attention if they occur.
Storage and Shelf Life
Xifaxan tablets should be stored at room temperature (20-25°C) in a dry place, protected from light and moisture. The shelf life of the medication is typically two to three years from the date of manufacture.
Pregnancy and Breastfeeding
The safety of Xifaxan during pregnancy and breastfeeding has not been established. It should be used during pregnancy or breastfeeding only if the potential benefits justify the potential risks to the fetus or infant.
Impact on Motor Functions
Xifaxan does not typically impair cognitive or motor functions. However, patients should be cautious when driving or operating machinery, especially if they experience dizziness or other central nervous system side effects.
Overdose
In the event of overdose, supportive measures should be initiated as needed. There is no specific antidote for rifaximin overdose, and treatment is symptomatic.
Conclusion
Xifaxan is an important antibiotic option for the treatment of traveler’s diarrhea and IBS-D, offering targeted therapy with minimal systemic absorption. By understanding Xifaxan’s mechanisms of action, indications, dosage, and precautions, patients and healthcare providers can work together to achieve optimal treatment outcomes in gastrointestinal disorders. Always consult a healthcare provider for personalized medical advice.